The use of the photocatalytic activity of nanoscaled anatase particles is intriguing. Whereas the effect has been known for a long time it is still a challenge to make the effect useful in everyday applications. We stress the importance of dispersion quality with respect to the application to produce highly efficient photocatalytic materials. Apart from the photocatalytic effect itself which is intrinsic to TiO2, the main challenges comprise the chemical degradation of the matrix, the particle integration into a suitable matrix, and the handling of the resulting material. Buhler has developed the chemomechanical process and uses this process to produce nanoscaled dispersions of inorganic oxides from agglomerated nano powders. Chemomechanical processing means chemical surface modification reaction under well-defined mechanical stress conditions. The chemical surface modification is a particular important feature of the process, because it allows chemical customization of a formulation. We present the production of photocatalytic TiO2 dispersions in water and organic solvents for various applications. TiO2 dispersions in water may be used in aqueous systems, whereas TiO2 in organic solvents can be integrated into suitable binders including screen printing pastes.