An integrated NMR/nanosensor system for sensitive detection of environmental toxins and harmful microbes

	Clean Technology 2007 Chapter 4: Enviroment, Health and Society
	An integrated NMR/nanosensor system for sensitive detection of environmental toxins and harmful microbes
Authors:	J.M. Perez, D.P. Fries and J.J. Hickman
Affilation:	University of Central Florida, US
Pages:	152 - 154
Keywords:	pathogens, toxins, sensing, iron oxide, magnetic nanoparticles
Abstract:	The use of nanoparticles and NMR detection technologies has lead to significant improvements in sensitivity. Nanoparticles have many useful optical and electronic properties derived from their small size. When coupled to affinity ligands, these materials have been utilized as chemical sensors such as fluorescent quantum dots and carbon nanotubes to detect DNA and to create immunoassays for the detection of bacteria and toxins However, these methods are limited in that they cannot be analyzed in turbid media, they require purification of the target molecule prior to analysis, and utilize non-portable instrumentation. One alternative is the use of non-toxic iron oxide based magnetic nanoparticles for highly sensitive detention of molecular targets. In this case, the classical label is replaced by a superparamagnetic nanoparticle, which can be detected magnetically. This investigator has developed an innovative detection approach that relies on the effect that iron oxide-based nanoparticles have on the NMR signal of neighboring water molecules, and utilize non-portable instrumentation.This NMR-based detection approach requires no separation; it is robust to interferences and has been performed in whole blood, lipid emulsion, and tissue culture media. The potential of the technique to detect other toxins and pathogens in clinical and environmental samples is being pursued.
ISBN:	1-4200-6382-0
Pages:	338
Order:	Online/Mail/Fax Ordering Options
Indexes:	Keywords, Authors, Affiliations
Up

Join Us

Featured Events

ARPA-E Energy Innovation Summit
Washington DC, Feb. 27-29, 2012

Cleantech 2012
(joint with TechConnect World)
Santa Clara CA, June 19-21, 2012

"We've very much enjoyed being a member of CTSI. In addition to the many networking and conference opportunities, we've found the monthly newsletters to be the best consolidated source of clean technology industry information and updates on policy, grants and market intelligence."

- Patrick J. Piper, QM Power, Inc.

"Ener-G-Rotors is pleased to be a member of CTSI. CTSI has been very supportive of our efforts in clean technology, helping to connect us with key legislators, introducing us to contacts at the DOE, and providing opportunities to network with other clean technology companies."

- Michael Newell, Ener-G-Rotors, Inc.

"The Clean Technology and Sustainable Industries Organization brings together the world's most innovative companies to provide critical thinking and technology solutions to real-world challenges."

- Dr. Ray O Johnson, Senior Vice President and Chief Technology Officer, Lockheed Martin

Clean Technology 2007

Chapter 4: Enviroment, Health and Society

An integrated NMR/nanosensor system for sensitive detection of environmental toxins and harmful microbes